Research
Advancing neuroscience through multi-omics and AI-driven approaches
Our Research Focus
We integrate cutting-edge technologies to decode the complexities of the human brain
Spatial Transcriptomics & Brain Architecture
Our laboratory pioneers the systematic characterization of cellular structural foundations underlying multiple cortical regions with complex functions. We establish comprehensive cellular atlases of the human cerebral cortex, bridging molecular profiling, spatial organization, and computational analysis to reveal how cellular diversity and organization give rise to higher-order cognitive functions.
Through innovative integration of single-cell multi-omics and spatial transcriptomics, we create multi-dimensional maps of human brain architecture, advancing our understanding of neural organization at unprecedented resolution.
AI & Computational Neuroscience
We stand at the forefront of integrating artificial intelligence with multi-omics approaches to decode intricate neural cellular networks and fundamental principles governing the human brain. Our advanced AI algorithms enable us to construct multi-dimensional maps of brain architecture, revealing patterns and relationships that would be impossible to discern through traditional methods.
By combining machine learning, deep learning, and innovative computational frameworks, we develop tools that transform raw biological data into actionable insights about brain function and organization.
Neuropsychiatric Disorders
Building upon our foundational knowledge of brain architecture, we extend our investigations to various neuropsychiatric disorders. By systematically comparing epileptic and healthy brain tissues, we have uncovered pathological alterations in cellular organizational structures within cortical and hippocampal regions.
This comparative approach provides unprecedented insights into the cellular mechanisms underlying epileptogenesis and associated cognitive impairments, opening new avenues for understanding disease pathophysiology at the cellular resolution and developing targeted therapeutic strategies.
Multi-Modal Brain Imaging
Our integrative framework combines spatial transcriptomics, neuroimaging, and mesoscopic imaging modalities to construct comprehensive views of human brain structure and function. This multi-modal approach allows us to bridge molecular, cellular, and systems-level understanding of the brain.
By integrating data across scales and modalities, we create holistic models that capture the complexity of neural organization in both health and disease states.